反应 #3236

反应方程式

7-bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione

choline hydroxide

→

title compound

收率 78.0%

7-Bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione choline salt

收率 78.0%

溶剂

methanol

反应条件

后处理

1. 1
   浓缩The resulting solution was concentrated
2. 2
   其他the solid yellow residue was recrystallized from ethanol

实验过程

To a suspension of 7-bromo-2,3-dihydro-10-hydroxypyridazino[4,5-b]quinoline-1,4-dione (0.600g, 1.95 mM) in methanol (20 mL) was added choline hydroxide (0.24 g, 1.98 mM, 45% solution in methanol). The resulting solution was concentrated and the solid yellow residue was recrystallized from ethanol to provide (0.62 g, 78%) the title compound as yellow crystals, mp 227.5°-228.5° C.

来源