反应 #3207

反应方程式

2-nitro-4-methoxybenzonitrile

acetic acid

sulfuric acid

→

benzoic acid

收率 91.8%

2-Nitro-4-methoxybenzoic acid

收率 91.8%

溶剂

water

water

反应条件

后处理

1. 1
   温度was refluxed for 11 hr
2. 2
   温度to cool
3. 3
   其他The resulting precipitate which formed
4. 4
   其他was collected
5. 5
   洗涤washed with water
6. 6
   其他dried

实验过程

A mixture of 2-nitro-4-methoxybenzonitrile (14.0 g, 78.6 mM) in a solution of acetic acid (28 mL), sulfuric acid (28 mL) and water (28 mL) was refluxed for 11 hr, allowed to cool and diluted with water (200 mL). The resulting precipitate which formed was collected, washed with water and dried to give the title benzoic acid (14.2 g, 91.8%) as a yellow crystalline solid; MS(CI): 198 (M+H).

来源