反应 #319982

反应方程式

3α-Acetoxy-5α-pregnan-20-one

N-bromosuccinimide

benzoyl peroxide

→

3α-Acetoxy-17α-bromo-5α-pregnan-20-one

溶剂

carbon tetrachloride

反应条件

后处理

1. 1
   温度The reaction mixture was cooled
2. 2
   过滤filtered
3. 3
   洗涤washed with sodium bisulfite, water, and brine
4. 4
   浓缩concentrated
5. 5
   其他to give a crude reddish oil

实验过程

3α-Acetoxy-5α-pregnan-20-one (3 g, 360.5 g/m, 8.3 mmol), N-bromosuccinimide (2.7 g, 178 g/m, 15 mmol), and benzoyl peroxide (200 mg, 242 g/m, 0.83 mmol) dissolved in 50 ml of carbon tetrachloride were refluxed overnight (ca. 16h). The reaction mixture was cooled, filtered, and washed with sodium bisulfite, water, and brine, and then concentrated to give a crude reddish oil.

来源