反应 #318727

反应方程式

water

8-(4-hydroxyphenylthio)-5,6,7,8-tetrahydroquinoline

sodium nitrate

lanthanum nitrate

→

8-(4-hydroxy-3-nitrophenylthio)-5,6,7,8-tetrahydroquinoline

收率 31.9%

溶剂

ether

hydrochloric acid

反应条件

后处理

1. 1
   萃取the mixture was extracted with chloroform
2. 2
   其他Removal of solvent
3. 3
   workup.WAITleft a yellow oil which
4. 4
   其他was purified by flash chromatography (Kieselgel 60; 10% ethyl acetate in dichloromethane)

实验过程

15.0 g (58 mmol) of 8-(4-hydroxyphenylthio)-5,6,7,8-tetrahydroquinoline in 90 ml of ether were added dropwise to a stirred solution of 4.96 g (58 mmol) of sodium nitrate and 0.25 g (58 mmol) of lanthanum nitrate in 60 ml of 5.5N hydrochloric acid at 0° to 5° C. in an ice-bath. Stirring was then continued under nitrogen for 24 hours, after which water was added and the mixture was extracted with chloroform. Removal of solvent left a yellow oil which was purified by flash chromatography (Kieselgel 60; 10% ethyl acetate in dichloromethane) to obtain 5.6 g (20%) of 8-(4-hydroxy-3-nitrophenylthio)-5,6,7,8-tetrahydroquinoline as yellow crystals (from ethanol).

来源