反应 #315786

反应方程式

4-Chloro-6,7-dimethoxyquinoline

ethyl salicylate

→

title compound

收率 63.3%

Ethyl 2-[(6,7-dimethoxy-4-quinolyl)oxy]benzoate

收率 63.3%

溶剂

o-dichlorobenzene

反应条件

后处理

1. 1
   温度The reaction solution was cooled to room temperature
2. 2
   其他the solvent was removed by distillation under the reduced pressure
3. 3
   workup.ADDITIONWater was then added to the residue
4. 4
   萃取the mixture was extracted with chloroform
5. 5
   洗涤The chloroform layer was washed with water
6. 6
   干燥was dried over anhydrous sodium sulfate
7. 7
   其他The solvent was removed
8. 8
   workup.DISTILLATIONby distillation under the reduced pressure
9. 9
   其他the residue was purified by column chromatography

实验过程

4-Chloro-6,7-dimethoxyquinoline (100 mg), ethyl salicylate (336 mg), and 4-dimethylaminopyridine (244 mg) were suspended in o-dichlorobenzene (1 ml), and the suspension was stirred at 120° C. overnight. The reaction solution was cooled to room temperature, and the solvent was removed by distillation under the reduced pressure. Water was then added to the residue, and the mixture was extracted with chloroform. The chloroform layer was washed with water and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-hexane to give the title compound (100 mg, yield 56%).

来源