反应 #312648

反应方程式

hydrochloric acid (HCl)-ethyl acetate

tert-butanol

N-methylmorpholine-N-oxide

1-benzyl-4-methyleneazepane hydrochloride

→

1-benzyl-4-(hydroxymethyl)azepane-4-ol hydrochloride

溶剂

THF water

反应条件

实验过程

A solution of tert-butanol of N-methylmorpholine-N-oxide and osmium tetroxide was added to a mixture of 1-benzyl-4-methyleneazepane hydrochloride and THF-water and stirred at room temperature for 24 hours. Then the reaction solution was processed with 4M hydrochloric acid (HCl)-ethyl acetate (EtOAc) solution to give 1-benzyl-4-(hydroxymethyl)azepane-4-ol hydrochloride. 10% palladium carbon was added to a solution of EtOH of the obtained 1-benzyl-4-(hydroxymethyl)azepane-4-ol hydrochloride and stirred for six hours at room temperature under the hydrogen atmosphere to give 4-(hydroxymethyl)azepane-4-ol hydrochloride.

来源