反应 #312642

反应方程式

3-[(4-bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide

NaOH

→

2-(4-bromo-2,5-difluorophenyl)thieno[3,2-d]pyrimidine-4(1H)-one

溶剂

MeOH

反应条件

实验过程

A mixture of 3-[(4-bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide; 1M NaOH aq and MeOH was stirred for two hours at 80° C. to give 2-(4-bromo-2,5-difluorophenyl)thieno[3,2-d]pyrimidine-4(1H)-one.

来源