反应 #312641

反应方程式

3-aminothiophene-2-carboxamide

N,N-diisopropylethylamine

4-bromo-2,5-difluorobenzoic acid

thionyl chloride

→

3-[(4-bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide

溶剂

THF

反应条件

后处理

1. 1
   其他the solution was removed
2. 2
   其他an oily substance was obtained
3. 3
   workup.STIRRINGwas stirred for two hours under ice cooling

实验过程

After stirring a mixture of 4-bromo-2,5-difluorobenzoic acid and thionyl chloride for one hour at 80° C., the solution was removed and an oily substance was obtained. A mixture of the obtained oily substance, 3-aminothiophene-2-carboxamide, N,N-diisopropylethylamine and THF was stirred for two hours under ice cooling to give 3-[(4-bromo-2,5-difluorobenzoyl)amino]thiophene-2-carboxamide.

来源