反应 #312639

反应方程式

dry ice

n-butyllithium

1-bromo-4-chloro-5-fluoro-2-(methoxymethoxy)benzene

→

lithium 4-chloro-5-fluoro-2-(methoxymethoxy)benzoate

溶剂

diethyl ether

diethyl ether

反应条件

后处理

1. 1
   workup.STIRRINGstirred for two hours

实验过程

n-butyllithium was added to a diethyl ether solution of 1-bromo-4-chloro-5-fluoro-2-(methoxymethoxy)benzene in a dry ice-acetone bath and stirred for one hour. The reaction solution was added to a mixture of dry ice and diethyl ether and stirred for two hours to give lithium 4-chloro-5-fluoro-2-(methoxymethoxy)benzoate. Phosphorus oxychloride was added to a mixture of the obtained lithium 4-chloro-5-fluoro-2-(methoxymethoxy)benzoate, 3-aminothiophene-2-carboxamide and pyridine in a MeOH ice bath and stirred for one hour to give 3-{[4-chloro-5-fluoro-2-(methoxymethoxy)benzoyl]amino}thiophene-2-carboxamide.

来源