反应 #312638

反应方程式

ammonia water

methyl 2-[(4-chloro-2,5-difluorobenzoyl)amino]nicotinate

→

2-(4-chloro-2,5-difluorophenyl)pyrido[2,3-d]pyrimidine-4(3H)-one

溶剂

chloroform MeOH

反应条件

实验过程

28% ammonia water was added to a chloroform-MeOH solution of methyl 2-[(4-chloro-2,5-difluorobenzoyl)amino]nicotinate and the resultant was stirred all night at room temperature to give 2-(4-chloro-2,5-difluorophenyl)pyrido[2,3-d]pyrimidine-4(3H)-one.

来源