反应 #312635

反应方程式

methyl 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylate

MeOH

sodium hydroxide

→

3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylic acid

溶剂

THF

反应条件

实验过程

A mixture of methyl 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylate, MeOH, THF and 1M sodium hydroxide (NaOH) solution (aq) was stirred for two hours at 85° C. to give 3-[(4-chloro-2,5-difluorobenzoyl)amino]thiophene-2-carboxylic acid.

来源