反应 #312632

反应方程式

{1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,6-dimethyl-thieno[3,2-d]pyrimidin-4-yl]-piperidin-4-yl}-acetic acid

iodoethane

K2CO3

H2O

→

title compound

收率 69.4%

{1-[7-(4-Bromo-2,6-dimethyl-phenyl)-2,6-dimethyl-thieno[3,2-d]pyrimidin-4-yl]-piperidin-4-yl}-acetic acid ethyl ester

收率 69.4%

溶剂

DMF

EtOAc

反应条件

后处理

1. 1
   其他separated
2. 2
   洗涤The organic layer washed brine
3. 3
   干燥dried over anhydrous Na2SO4
4. 4
   浓缩concentrated under reduced pressure
5. 5
   其他The residue was purified by a silica gel column chromatography (silica gel: Wako Gel (C200), eluent: Hexane/EtOAc=4:1)

实验过程

A mixture of {1-[7-(4-bromo-2,6-dimethyl-phenyl)-2,6-dimethyl-thieno[3,2-d]pyrimidin-4-yl]-piperidin-4-yl}-acetic acid (30 mg), iodoethane (97 mg) and K2CO3 (17 mg) in DMF (1 mL) was stirred at room temperature for 16 hours. To the reaction mixture were added H2O and EtOAc and separated. The organic layer washed brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel: Wako Gel (C200), eluent: Hexane/EtOAc=4:1) to obtain the title compound (22 mg) as a white crystal.

来源