反应 #312609

反应方程式

1-(phenylsulfonyl)-4-piperazin-1-yl-1H-indole

benzyl bromide

triethyl-amine

→

title product

4-(4-Benzylpiperazin-1-yl)-1-(phenyl-sulfonyl)-1H-indole

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   浓缩concentrated in vacuo
2. 2
   其他to give a residue
3. 3
   其他The residue is purified by RP-HPLC

实验过程

A solution of 1-(phenylsulfonyl)-4-piperazin-1-yl-1H-indole (71 mg, 0.18 mmol) in tetrahydrofuran is treated sequentially with benzyl bromide (21 μl) and triethyl-amine (75 μl ), shaken at room temperature for 16 hr and concentrated in vacuo to give a residue. The residue is purified by RP-HPLC to give the title product, 37 mg, identfied by HPLC and mass spectral analyses (2.81 min; 432 M+H) using the LCMS conditions described in Table I.

来源