反应 #309

反应方程式

CN1Cc2ccc(Cl)nc2O[C@

Cc1ncn(-c2ccc(N)cc2)

→

Cc1ncn(-c2ccc(Nc3ccc

溶剂

COCCOC

反应条件

实验过程

A solution of (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (5.00 mg, 0.02 mmol) and 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (3.17 mg, 0.02 mmol) in DME (.5 mL) was added via a syringe to a capped microwave vial containing PALLADIUM(II) ACETATE (0.409 mg, 1.82 µmol), 2-(DICYCLOHEXYLPHOSPHINO)BIPHENYL (0.638 mg, 1.82 µmol) and CESIUM CARBONATE (8.89 mg, 0.03 mmol) under an argon atmosphere. The resulting mixture was heated to 100°C in a microwave apparatus for 1 h and analyzed by LCMS. No product.

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