反应 #3059

反应方程式

O-benzylhydroxylamine hydrochloride

bromoacetyl bromide

diisopropylethylamine

→

title compound

收率 52.0%

Bromo-N-(benzyloxyl)acetamide

收率 52.0%

溶剂

ethyl acetate

water

THF

反应条件

后处理

1. 1
   其他The aqueous layer was separated
2. 2
   萃取extracted with ethyl acetate
3. 3
   干燥dried over Na2SO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated in vacuo
6. 6
   其他The crude material was purified by silica gel flash column chromatography with ethyl acetate-hexane

实验过程

To a 0° C. solution of O-benzylhydroxylamine hydrochloride (1.6 g, 10 mmol) in THF (40 mL) was added bromoacetyl bromide (871 μL, 10 mmol) and diisopropylethylamine (3.5 mL, 20 mmol). The reaction mixture was warmed to room temperature overnight and diluted with ethyl acetate and water. The aqueous layer was separated and extracted with ethyl acetate. The organic layers were combined, dried over Na2SO4, filtered and concentrated in vacuo. The crude material was purified by silica gel flash column chromatography with ethyl acetate-hexane to give 1.27 g (52%) of the title compound.

来源