反应 #302923

反应方程式

N-methylpiperazine

2,4-dichloro-thieno[3,2-d]pyrimidine

K2CO3

→

desired product

收率 85.6%

2-Chloro-4-(4-methyl-piperazin-1-yl)-thieno[3,2-d]pyrimidine

收率 85.6%

溶剂

EtOH

反应条件

后处理

1. 1
   过滤the mixture was filtered

实验过程

To a solution of 2,4-dichloro-thieno[3,2-d]pyrimidine (0.20 g, 1.0 mmol) in EtOH (3.2 mL) was added K2CO3 (0.31 g, 2.2 mmol) followed by N-methylpiperazine (0.13 mL, 1.2 mmol). After stirring at rt for 12 h, the mixture was filtered to afford 0.23 g of the desired product. MS: 269.0. 1H NMR (400 MHz, CD3OD) δ ppm 8.06 (d, J=5.6 Hz, 1H), 7.27 (d, J=5.6 Hz, 1H), 4.05-4.00 (m, 4H), 2.62-2.56 (m, 4H), 2.36 (s, 3H).

来源