反应 #302921

反应方程式

3-ethoxycarbonylamino-thiophene-2-carboxylic acid methyl ester

hydrazine monohydrate

→

powder

收率 61.9%

3-Amino-1H-thieno[3,2-d]pyrimidine-2,4-dione

收率 61.9%

溶剂

EtOH

反应条件

后处理

1. 1
   过滤the mixture was filtered

实验过程

To a solution of 3-ethoxycarbonylamino-thiophene-2-carboxylic acid methyl ester (3.43 g, 15.0 mmol) in EtOH (100 mL) was added hydrazine monohydrate (7.98 mL, 164.6 mmol). After heating at 90° C. for 12 h, the mixture was filtered to afford a fine yellow powder (1.70 g), which was used in the next step without further purification. MS: 184.2. 1H NMR (400 MHz, CD3OD) δ ppm 7.93 (d, J=5.3 Hz, 1H), 6.95 (d, J=5.3 Hz, 1H).

来源