反应 #302892

反应方程式

2,3-dimethylbenzylamine

2-chloroethylisothiocyanate

→

title compound

收率 76.0%

((2,3-dimethylphenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

收率 76.0%

溶剂

1,4-dioxane

反应条件

后处理

1. 1
   温度to cool
2. 2
   其他a solid precipitate that had formed
3. 3
   过滤was collected by filtration
4. 4
   洗涤The solid was rinsed with diethyl ether
5. 5
   其他was dried under reduced pressure

实验过程

Under a dry nitrogen atmosphere, a stirred mixture of 5.56 grams (0.041 mole) of 2,3-dimethylbenzylamine and 5.0 grams (0.041 mole) of 2-chloroethylisothiocyanate in 100 mL of 1,4-dioxane was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 8.0 grams of the title compound. The NMR spectrum was consistent with the proposed structure.

来源