反应 #302891

反应方程式

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Compound C7

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

sodium hydroxide

→

title compound

收率 98.9%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine

收率 98.9%

溶剂

water

water

diethyl ether

反应条件

后处理

1. 1
   workup.ADDITIONpoured into a separatory funnel
2. 2
   萃取was extracted with two 50 mL portions of diethyl ether
3. 3
   干燥dried with sodium sulfite
4. 4
   过滤filtered
5. 5
   浓缩The filtrate was concentrated under reduced pressure

实验过程

A mixture of 0.36 gram (0.0012 mole) of ((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride (Compound C7) in one mL of water was added to a stirred, cold (ice water bath) mixture of 0.05 gram (0.0013 mole) of sodium hydroxide in 10 mL of water and 10 mL of diethyl ether. The reaction mixture was stirred for 10 minutes, poured into a separatory funnel and was extracted with two 50 mL portions of diethyl ether. The extracts were combined, dried with sodium sulfite and filtered. The filtrate was concentrated under reduced pressure to yield 0.31 gram of the title compound as a white solid. The NMR spectrum was consistent with the proposed structure.

来源