反应 #302862

ord-e4a4856015b747faa4a7eb10e50a9f34

反应方程式

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine
→
CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.NCCc1c[nH]cn1.O=C(O)CCC(=O)O
histamine dipalmitoylglycerol succinate

反应物

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine

试剂

无

溶剂

CN(C)C=O
DMF
CN(C)C=O
DMF

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    workup.STIRRINGThe mixture is stirred overnight
  2. 2
    浓缩concentrated thoroughly in vacuum
  3. 3
    其他The residue is purified

实验过程

1.7 g of dipalmitoylglycerol succinate is dissolved in 20 ml of DMF at room temperature. The solution is added with 400 mg of carbonyldiimidazole dissolved in 20 ml of DMF. The mixture is allowed to stir for 1 hour and subsequently added with 300 mg of histamine. The mixture is stirred overnight and concentrated thoroughly in vacuum. The residue is purified using column chromatography on silica gel 60, with chloroform/methanol 10:1 being used as eluant.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08192753B2uspto-grants-2012_06