反应 #302847

反应方程式

compound 3

1-(5-bromo-2-hydroxyphenyl)-3-(4-nitrophenyl)propan-1,3-dione

sulfuric acid

→

compound 4

6-bromo-4′-nitroflavone

溶剂

acetic acid

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度to reflux for 1 hour
3. 3
   其他was returned to room temperature
4. 4
   workup.ADDITIONice pieces were then added to the reaction solution
5. 5
   过滤The precipitated crystal was collected by filtration

实验过程

A mixed solution consisting of compound 3 (2.00 g, 5.49 mmol), concentrated sulfuric acid (0.5 ml), and acetic acid (40 ml) was heated to reflux for 1 hour. The temperature of the resultant was returned to room temperature, and ice pieces were then added to the reaction solution. The precipitated crystal was collected by filtration, so as to obtain a product of interest, 6-bromo-4′-nitroflavone (compound 4). Yield: 1.79 g (yield constant: 94.2%) MS m/z 347 (MH+).

来源