反应 #3028

反应方程式

hydrochloric acid

2,4-dinitrophenol

octadecyl bromide

sodium carbonate

→

1-octadecyloxy-2,4-dinitrobenzene

收率 79.1%

溶剂

dimethylformamide

water

反应条件

后处理

1. 1
   萃取extracted with ether
2. 2
   洗涤The extracts were washed with water and brine
3. 3
   干燥dried over magnesium sulfate
4. 4
   其他The solvent was removed
5. 5
   其他the solid recrystallized

实验过程

A mixture of 2,4-dinitrophenol (85 wt %, 6.72 g, 31 mmol), octadecyl bromide (20.7 g, 62 mmol), sodium carbonate (6.57 g, 62 mmol) and dimethylformamide (31 mL) was heated to 100° C. under a nitrogen atmosphere for 22 h. The cooled mixture was diluted with water (200 mL), acidified with 10N hydrochloric acid (50 mL) and extracted with ether. The extracts were washed with water and brine, and dried over magnesium sulfate. The solvent was removed and the solid recrystallized to give 1-octadecyloxy-2,4-dinitrobenzene (10.7 g, 79%): mp 63.5°-64.0° C.

来源