反应 #2947

反应方程式

diketene acetone

dimethylamine

→

title compound

N,N-Dimethyl-3-oxobutyramide

溶剂

toluene

反应条件

后处理

1. 1
   其他The solvent was removed in vacuo
2. 2
   其他the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

实验过程

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

来源