反应 #2898

反应方程式

iodomethane

4-Bromo-3,5-dimethylpyrazole

sodium hydride

sodium hydrogen carbonate

hydrogen

→

title compound

4-Bromo-1,3,5-trimethylpyrazole

溶剂

dimethylformamide

dimethylformamide

反应条件

后处理

1. 1
   workup.ADDITIONwas added
2. 2
   其他evaporation under high vacuum
3. 3
   其他the residue was purified by column chromatography

实验过程

4-Bromo-3,5-dimethylpyrazole (10 g) in dry dimethylformamide (50 ml) was added to a stirred suspension of sodium hydride (1.8 g) in dry dimethylformamide at 0° C. When the evolution of hydrogen was complete, iodomethane (8.9 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes saturated aqueous sodium hydrogen carbonate (5 ml) was added. Following evaporation under high vacuum, the residue was purified by column chromatography to give the title compound.

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