反应 #2891

反应方程式

sodium chloride

n-butyllithium

3-Bromofuran

N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide

→

title compound

3-Furyl 4-Methyl-5-oxazolyl Ketone

溶剂

Ethanol

diethylether

diethylether

反应条件

后处理

1. 1
   workup.WAITAfter a further 30 minutes the mixture was allowed
2. 2
   温度to warm to room temperature
3. 3
   萃取The mixture was extracted with dichloromethane
4. 4
   其他the material thus obtained
5. 5
   其他was purified by flash chromatography

实验过程

3-Bromofuran (2.5 g) in dry diethylether was stirred and cooled to -70° C. under an atmosphere of dry nitrogen and n-butyllithium (2.5M solution in hexane, 6.8 ml) was added dropwise. After 30 minutes, N-methoxy-N-methyl-4-methyl-5-oxazolecarboxamide (2.89 g) in dry diethylether was added dropwise. After a further 30 minutes the mixture was allowed to warm to room temperature. Ethanol (5 ml) was added followed by saturated aqueous sodium chloride. The mixture was extracted with dichloromethane and the material thus obtained was purified by flash chromatography to give the title compound. M.p. 82°-83.5° C.

来源