反应 #2843

反应方程式

K2CO3

benzo[b]thiophene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

methyl iodide

→

title compound

收率 96.7%

Benzo[b]thiophene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-methylamide

收率 96.7%

溶剂

H2O

EtOAc

DMF

反应条件

后处理

1. 1
   其他The layers are separated
2. 2
   洗涤The organic layer is washed with H2O and saturated NaCl
3. 3
   干燥The organic layer is dried over MgSO4
4. 4
   过滤filtered
5. 5
   浓缩concentrated
6. 6
   其他The residue is triturated with Et2O

实验过程

To a solution of benzo[b]thiophene-2-sulfonic acid [1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide (0.25 g, 0.61 mmol) in 3 mL of DMF is added methyl iodide (0.13 g, 0.91 mmol) followed by K2CO3 (0.13 g, 0.91 mmol). The solution is stirred at ambient temperatures for 6 h. After this time, the solution is diluted with H2O and EtOAc. The layers are separated. The organic layer is washed with H2O and saturated NaCl. The organic layer is dried over MgSO4, filtered and concentrated. The residue is triturated with Et2O to give the title compound (0.25 g, 0.59 mmol) as a white solid.

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