反应 #2800

ord-5676a3bcc4df4c039dcca17382f31a6c

反应方程式

C=Cc1ccccc1CI
1-iodomethyl-2-vinyl-benzene
CC1(C)C2CCC13CS(=O)(=O)N(C(=O)CN=C(S(C)(=O)=O)S(C)(=O)=O)C3C2
2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-ethanone
→
C=Cc1ccccc1CC(N=C(S(C)(=O)=O)S(C)(=O)=O)C(=O)N1C2CC3CCC2(CS1(=O)=O)C3(C)C
2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-3-(2-vinyl-phenyl)-propan-1-one

反应物

—
( 3 )
C=Cc1ccccc1CI
1-iodomethyl-2-vinyl-benzene
CC1(C)C2CCC13CS(=O)(=O)N(C(=O)CN=C(S(C)(=O)=O)S(C)(=O)=O)C3C2
2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-ethanone

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

In step c, the appropriate 1-iodomethyl-2-vinyl-benzene derivative of structure (3) is subjected to an addition, elimination reaction with 2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-ethanone (4) to give the corresponding 2-(bis-methylsulfonyl-methyleneamino)-1-(10,10-dimethyl-3,3-dioxo-3-thia-4-aza-tricyclo[5.2.1.0 1,5]dec-4-yl)-3-(2-vinyl-phenyl)-propan-1-one derivative of structure (5).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05731306uspto-grants-1998_03