反应 #2799

反应方程式

chloroacetyl chloride

N-methylmorpholine

morpholine

→

chloroacetic acid morpholine carboxamide

溶剂

dichloromethane

反应条件

后处理

1. 1
   温度Cool in an ice-bath
2. 2
   萃取Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
3. 3
   干燥Dry the organic layer over Na2SO4
4. 4
   过滤filter
5. 5
   其他evaporate in vacuo

实验过程

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain chloroacetic acid morpholine carboxamide.

来源