反应 #2572

反应方程式

sodium hydroxide

hydrochloric acid

tin

4-Nitro-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide

→

title compound

收率 98.3%

4-Amino-N-{2[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxy-phenyl)benzamide

收率 98.3%

溶剂

—

ice water

chloroform

methanol

反应条件

后处理

1. 1
   温度while cooling in an ice bath
2. 2
   其他to remove insoluble materials
3. 3
   洗涤The resulting residue was washed with chloroform
4. 4
   萃取the filtrate was extracted with chloroform
5. 5
   洗涤the resulting organic layer was washed with water and saturated brine
6. 6
   干燥dried on anhydrous sodium sulfate
7. 7
   其他Thereafter, the solvent was removed by evaporation
8. 8
   其他the resulting residue was purified by a silica gel column chromatography (chloroform:methanol=10:1)

实验过程

4-Nitro-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide (264.0 mg, 0.52 mmol) was dissolved in methanol (5 ml) to which were subsequently added concentrated hydrochloric acid (2.0 ml) and tin (powder, 186.0 mg, 1.57 mmol) while cooling in an ice bath. After 1 hour of stirring at room temperature, the reaction solution was poured in ice water, adjusted to pH 9 to 10 with 10% sodium hydroxide aqueous solution, mixed with chloroform and then passed through cerite to remove insoluble materials. The resulting residue was washed with chloroform, the filtrate was extracted with chloroform, and the resulting organic layer was washed with water and saturated brine, and dried on anhydrous sodium sulfate. Thereafter, the solvent was removed by evaporation, and the resulting residue was purified by a silica gel column chromatography (chloroform:methanol=10:1) to obtain 243.0 mg (97.9%) of the title compound in a colorless amorphous form.

来源