反应 #2560

反应方程式

N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide

triethylamine

→

title compound

收率 65.6%

N-Formylmethyl-3-methoxy-N-(2-methoxyphenyl)benzamide

收率 65.6%

溶剂

DMSO

DMSO

反应条件

后处理

1. 1
   其他at room temperature
2. 2
   萃取extracted with ethyl acetate
3. 3
   洗涤washed with water and saturated brine
4. 4
   干燥The resulting organic layer was dried on anhydrous magnesium sulfate
5. 5
   其他the solvent was removed by evaporation

实验过程

In an atmosphere of argon, N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide (339 mg, 1.12 mmol) was dissolved in DMSO (4 ml) to which were subsequently added dropwise triethylamine (0.724 ml, 5.20 mmol) and a DMSO solution (8 ml) of a sulfur trioxide-pyridine complex (844 mg, 5.20 mmol) at room temperature. After 20 minutes of stirring at the same temperature, this was mixed with ice water (40 ml) and extracted with ethyl acetate, and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous magnesium sulfate, and the solvent was removed by evaporation to obtain 220 mg (65.6%) of the title compound the form of light yellow solid.

来源