反应 #2555

反应方程式

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine hydrochloride

sodium carbonate

→

title compound

收率 92.3%

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine

收率 92.3%

溶剂

ether

反应条件

后处理

1. 1
   温度With cooling in an ice bath
2. 2
   萃取The reaction solution was extracted with ether
3. 3
   洗涤washed with saturated brine
4. 4
   干燥the resulting organic layer was dried on anhydrous sodium carbonate
5. 5
   过滤Thereafter, the organic layer was filtered through silica gel (5 g)
6. 6
   其他the solvent was removed by evaporation
7. 7
   其他the resulting residue was purified

实验过程

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine hydrochloride (800 mg, 2.61 mmol) was suspended in ether (20 ml). With cooling in an ice bath, saturated sodium carbonate aqueous solution (5 ml) was added dropwise to the suspension. The reaction solution was extracted with ether and washed with saturated brine, and the resulting organic layer was dried on anhydrous sodium carbonate. Thereafter, the organic layer was filtered through silica gel (5 g), the solvent was removed by evaporation and then the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 650 mg (92.3%) of the title compound in the form of light yellow solid.

来源