反应 #2516

ord-fc00450aae7f43bba3081ae919487779

反应方程式

COc1cccc(CN)c1
3-methoxybenzylamine
O=C(Cl)c1ccc(CCl)cc1
4-chloromethylbenzoyl chloride
COc1cccc(CNC(=O)c2ccc(CCl)cc2)c1
title compound
收率 83.9%
COc1cccc(CNC(=O)c2ccc(CCl)cc2)c1
4-Chloromethyl-N-(3-methoxybenzyl)benzamide
收率 83.9%

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Using 3-methoxybenzylamine (754 mg, 5.39 mmol) and 4-chloromethylbenzoyl chloride (1.17 g, 6.0 mmol), the procedure of Reference Example 13 was repeated to obtain 1.31 g (83.9%) of the title compound in the form of colorless crystals.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05728835uspto-grants-1998_03