反应 #2507854

反应方程式

2′-hydroxy-3′-nitrobiphenyl-3-carboxylic acid

→

3′-amino-2′-hydroxybiphenyl-3-carboxylic acid

收率 94.1%

溶剂

methanol

反应条件

后处理

1. 1
   过滤The reaction mixture was filtered
2. 2
   浓缩concentrated

实验过程

A solution of 2′-hydroxy-3′-nitrobiphenyl-3-carboxylic acid (800 g, 3.2 mol) in methanol (5 L) was hydrogenated over 5% Pd/C (160 g) at room temperature for 8 hours. The reaction mixture was filtered, concentrated and slurried in THF (2.5 L) to give 3′-amino-2′-hydroxybiphenyl-3-carboxylic acid (690 g, 50.5%) as a brown solid. PXRD analysis provided the diffractogram as shown in FIG. 32.

来源