反应 #2507848

反应方程式

3-t-Butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)pyrazole

tetrabutylammonium fluoride tetrahydrofuran

→

desired compound

收率 46.4%

1,2-dihydro-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)-3H-pyrazol-3-one

收率 46.4%

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   浓缩The reaction solution was concentrated
2. 2
   其他the residue was purified on a silica gel column chromatography (ethyl acetate-hexane=1:4)

实验过程

3-t-Butyldimethylsilyloxy-4-((4-ethylphenyl)methyl)-1-(1,3-difluoro-2-propyl)-5-(trifluoromethyl)pyrazole (1.95 g; 4.22 mmol) was dissolved in tetrahydrofuran (30 ml) and cooled to 0° C. A 1 M tetrabutylammonium fluoride-tetrahydrofuran solution (6.33 ml; 6.33 mmol) was gradually added, then the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated, and the residue was purified on a silica gel column chromatography (ethyl acetate-hexane=1:4) to give the desired compound (684 mg; 1.96 mmol). (46%)

来源