反应 #2507844

反应方程式

2-propynyl 2-chloro-5-fluoro-4-(2-propynyloxy)benzoate

sodium hydroxide

hydrochloric acid

→

2-chloro-5-fluoro-4-(2-propynyloxy)benzoic acid

收率 61.4%

溶剂

methanol

反应条件

后处理

1. 1
   其他obtained above, and
2. 2
   过滤Then, a produced solid was collected by filtration
3. 3
   洗涤The solid was washed with a MTBE-hexane mixed solvent

实验过程

To a mixture of 30 ml of methanol and 30 ml of a 15% aqueous sodium hydroxide solution was added 19 g of 2-propynyl 2-chloro-5-fluoro-4-(2-propynyloxy)benzoate obtained above, and then stirred at 50° C. for 2 hours. The reaction mixture was made acidic by addition of hydrochloric acid. Then, a produced solid was collected by filtration. The solid was washed with a MTBE-hexane mixed solvent, and 10 g of 2-chloro-5-fluoro-4-(2-propynyloxy)benzoic acid was obtained.

来源