反应 #2507840

反应方程式

bromobenzene

2,5-dichloro-2,5-dimethyl hexane

Aluminum chloride

→

6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他A 200 ml round-bottomed flask equipped with a stir bar and a reflux condenser
2. 2
   温度until spontaneous reflux subsides
3. 3
   其他the layers were separated
4. 4
   萃取The aqueous layer was extracted with EtOAc (5×20 ml)
5. 5
   洗涤The combined organic layer was washed with water and brine
6. 6
   干燥dried over sodium sulfate
7. 7
   过滤filtered
8. 8
   浓缩concentrated

实验过程

A 200 ml round-bottomed flask equipped with a stir bar and a reflux condenser was charged with a solution of bromobenzene (109 mmol, 17 ml) and 2,5-dichloro-2,5-dimethyl hexane (10 grams, 54.6 mmol) in dichloromethane (30 ml). Aluminum chloride (1.45 grams, 10.9 mmol) was added to the solution slowly, until spontaneous reflux subsides. After stirring for 10-15 minutes at room temperature, the reaction was poured into ice water (30 ml) and the layers were separated. The aqueous layer was extracted with EtOAc (5×20 ml). The combined organic layer was washed with water and brine, dried over sodium sulfate, filtered, and concentrated, to yield a 6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene product.

来源