反应 #2507829

反应方程式

6-fluoro-3-pentylchroman-7-carbaldehyde

sodium borohydride

→

(6-fluoro-3-pentylchroman-7-yl)methanol

溶剂

water

ethanol

反应条件

后处理

1. 1
   萃取extracted three times with MTB ether
2. 2
   洗涤phases are washed with sat. sodium chloride soln
3. 3
   干燥and dried over sodium sulfate
4. 4
   其他the solvent is removed in vacuo
5. 5
   过滤the residue is filtered through silica gel with dichloromethane (Rf=0.3)

实验过程

11.1 g (44.3 mmol) of 6-fluoro-3-pentylchroman-7-carbaldehyde are dissolved in 100 ml of ethanol, and 2.0 g (52.8 mmol) of sodium borohydride are added in portions. After 3 h, the batch is diluted with water and extracted three times with MTB ether. The combined org. phases are washed with sat. sodium chloride soln. and dried over sodium sulfate, the solvent is removed in vacuo, and the residue is filtered through silica gel with dichloromethane (Rf=0.3), giving (6-fluoro-3-pentylchroman-7-yl)methanol as a colourless solid.

来源