反应 #2487504

反应方程式

N2

1-{3-[7-(3-methyl-3H-imidazol-4-ylethynyl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea

→

product

收率 9.2%

1-(3-{7-[2-(3-Methyl-3H-imidazol-4-yl)-ethyl]-imidazol[1,2-a]pyridin-3-yl}-phenyl)-3-(2,2,2-trifluoro-ethyl)-urea

收率 9.2%

溶剂

MeOH

反应条件

后处理

1. 1
   workup.ADDITIONThe flask was filled with H2
2. 2
   过滤The reaction was filtered
3. 3
   浓缩the filtrate concentrated in vacuo
4. 4
   其他The crude product was purified by preparative HPLC

实验过程

To an evacuated flask back-filled with N2 containing 1-{3-[7-(3-methyl-3H-imidazol-4-ylethynyl)-imidazo[1,2-a]pyridin-3-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (65.7 mg, 0.15 mmol) in MeOH was added Pd (10 wt % on activated carbon) (25.5 mg). The flask was filled with H2 and the reaction stirred for a total of 7.5 hours. The reaction was filtered and the filtrate concentrated in vacuo. The crude product was purified by preparative HPLC to give pure product (6.1 mg). MS: [M+H]+443.

来源