反应 #2487490

反应方程式

4-(11-Methoxycarbonylundecyl)benzoic acid tert-butyl ester

NaOH

AcOEt

→

4-(11-Methoxycarbonylundecyl)benzoic Acid

溶剂

THF

反应条件

后处理

1. 1
   洗涤the solution was washed with 5% AcOH (2×25 ml)
2. 2
   干燥dried over MgSO4
3. 3
   浓缩concentrated under vacuum to the product (153 mg)

实验过程

4-(11-Methoxycarbonylundecyl)benzoic acid tert-butyl ester (185 mg, 0.47 mmol) was dissolved in THF (2 ml), and 1 N NaOH (0.497 mmol) was added over 1 min. The mixture was stirred for 16 h at rt. AcOEt (50 ml) was added and the solution was washed with 5% AcOH (2×25 ml), dried over MgSO4 and concentrated under vacuum to the product (153 mg).

来源