反应 #2487488

反应方程式

12-Bromododecanoic acid methyl ester

Sodium iodide

→

oil

收率 97.0%

12-Iodododecanoic Acid Methyl Ester

收率 97.0%

溶剂

acetone

反应条件

后处理

1. 1
   温度the reaction was refluxed under nitrogen for 20 h
2. 2
   浓缩The sample was concentrated under vacuum
3. 3
   workup.ADDITIONWater (100 ml) was added
4. 4
   萃取the mixture was extracted with AcOEt (2×100 ml)
5. 5
   洗涤washed with water
6. 6
   干燥a small amount of sat. NaCl and sat. NaCl (100 ml each), dried over MgSO4
7. 7
   浓缩concentrated

实验过程

12-Bromododecanoic acid methyl ester (5.65 g, 19.3 mmol) was dissolved in acetone (50 ml). Sodium iodide (14.4 g, 96 mmol) was added and the reaction was refluxed under nitrogen for 20 h. The sample was concentrated under vacuum. Water (100 ml) was added, and the mixture was extracted with AcOEt (2×100 ml). The organic extracts were pooled and washed with water plus a small amount of sat. NaCl and sat. NaCl (100 ml each), dried over MgSO4, and concentrated to yield a light yellow oil (6.37 g, 97%).

来源