反应 #2487475

反应方程式

ethyl 5-(6-chloro-5-methoxy-2-phenylindol-1-ylmethyl)furan-2-carboxylate

ammonia

→

title compound

5-(6-Chloro-5-methoxy-2-phenylindol-1-ylmethyl)furan-2-carboxamide

反应条件

后处理

1. 1
   过滤The reaction mixture was filtered
2. 2
   洗涤washed with methanol
3. 3
   浓缩concentrated under reduced pressure

实验过程

A suspension of ethyl 5-(6-chloro-5-methoxy-2-phenylindol-1-ylmethyl)furan-2-carboxylate (258 mg) in ammonia (Ca. 7 mol/L methanol solution, 12.4 mL) was stirred at room temperature for 44 hours. The reaction mixture was filtered, washed with methanol, and then concentrated under reduced pressure to obtain the title compound (138 mg). 1H-NMR (CDCl3) δ ppm: 3.95 (3H, s), 5.23 (2H, s), 6.10 (1H, d, J=3.5 Hz), 6.50-6.55 (1H, m), 7.03 (1H, d, J=3.5 Hz), 7.15 (1H, s), 7.35-7.55 (6H, m).

来源