反应 #2487463

反应方程式

Water

sodium hydrogen carbonate

hydroxylamine hydrochloride

6-(5-methoxy-2-phenylindol-1-ylmethyl)pyridine-2-carbonitrile

→

title compound

收率 99.1%

6-(5-Methoxy-2-phenylindol-1-ylmethyl)pyridine-2-carboxamidoxime

收率 99.1%

溶剂

dimethylsulfoxide

反应条件

后处理

1. 1
   workup.STIRRINGby stirring at 80° C. overnight
2. 2
   萃取followed by extraction with ethyl acetate
3. 3
   洗涤The organic layer was washed with water and saturated brine
4. 4
   干燥dried over anhydrous magnesium sulfate
5. 5
   浓缩concentrated under reduced pressure

实验过程

To a suspension of hydroxylamine hydrochloride (233 mg) in dimethylsulfoxide (1.7 mL) was added sodium hydrogen carbonate (338 mg), and this mixture was stirred at 50° C. for 1 hour. Subsequently, 6-(5-methoxy-2-phenylindol-1-ylmethyl)pyridine-2-carbonitrile (114 mg) was added thereto, followed by stirring at 80° C. overnight. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain the title compound (124 mg). 1H-NMR (DMSO-d6) δ ppm: 3.76 (3H, s), 5.51 (2H, s), 5.65 (2H, br s), 6.59 (1H, s), 6.70-6.85 (2H, m), 7.11 (1H, d, J=2.4 Hz), 7.32 (1H, d, J=8.9 Hz), 7.35-7.70 (7H, m), 9.92 (1H, s).

来源