反应 #2487446

反应方程式

2-amino-4-(trifluoromethyl)benzamide

4-chlorobenzaldehyde

→

2-(4-Chlorophenyl)-7-trifluoromethyl-3H-quinazolin-4-one

溶剂

water

反应条件

后处理

1. 1
   温度The reaction mixture was then heated
2. 2
   温度at reflux for 24 h
3. 3
   其他the precipitate was isolated by vacuum filtration
4. 4
   洗涤washing with water (3×500 mL)
5. 5
   其他dried under vacuum (10 mbar, 50° C.)
6. 6
   其他3.7 min, 325 (M+)

实验过程

To a stirred suspension of 2-amino-4-(trifluoromethyl)benzamide (33.6 g, 0.16 mol) in water (750 mL) was added dropwise 4-chlorobenzaldehyde. Iron trichloride hexahydrate (133 g) was then added in portions. The reaction mixture was then heated at reflux for 24 h. After allowing the suspension to cool to room temperature, the precipitate was isolated by vacuum filtration washing with water (3×500 mL) and dried under vacuum (10 mbar, 50° C.). Yield=50 g, 94%; HPLC-mass spectrometry (LC-MS): 3.7 min, 325 (M+).

来源