反应 #2467947

ord-80affb7eb23e4bd3842fa7721b6694e5

反应方程式

CCOC(=O)C(CNc1nc(-c2ccccc2)cs1)Cc1ccccc1
2-Benzyl-3-(4-phenyl-thiazol-2-ylamino)-propionic ethyl ester
[K+].[OH-]
KOH
O=S(=O)([O-])O.[K+]
KHSO4
O=C(O)C(CNc1nc(-c2ccccc2)cs1)Cc1ccccc1
2-Benzyl-3-(4-phenyl-thiazol-2-ylamino)-propionic acid

溶剂

反应条件

详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    其他lyophilized before purification

实验过程

To a solution of 2-Benzyl-3-(4-phenyl-thiazol-2-ylamino)-propionic ethyl ester (22r) (0.028 mmol, 10 mg) in EtOH (2 mL) and water (200 μL) is added KOH 1N solution (224 μL, 8 eq.). After 5 hours, the solution is neutralized with KHSO4 1N solution and lyophilized before purification.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US08257931B2uspto-grants-2012_09