反应 #2467943

反应方程式

2-benzylmalonic acid diethyl ester

KOH

→

final product

2-Benzyl-malonic acid monoethyl ester

溶剂

EtOH

EtOH

反应条件

后处理

1. 1
   其他The solvent was removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting liquid dissolved in 5% NaHCO3 (30 mL)
3. 3
   洗涤washed with EtOAc (3×10 mL)
4. 4
   萃取back extracted with 5% NaHCO3 (50 mL)
5. 5
   萃取extracted with EtOAc
6. 6
   洗涤The organic layer was washed with H2O
7. 7
   干燥dried with Na2SO4
8. 8
   其他The solvent was removed under reduced pressure

实验过程

To a solution of 2-benzylmalonic acid diethyl ester 2.5 g (10 mmol) in EtOH (10 mL) was added 1N KOH in EtOH (8.5 mL). The solution was stirred for 1 h at room temperature. The solvent was removed under reduced pressure, and the resulting liquid dissolved in 5% NaHCO3 (30 mL), washed with EtOAc (3×10 mL), and back extracted with 5% NaHCO3 (50 mL). The combined NaHCO3 solutions were acidified to pH=3 with 1N HCl and extracted with EtOAc. The organic layer was washed with H2O, dried with Na2SO4. The solvent was removed under reduced pressure to give final product as oil, 1.4 g (74%).

来源