反应 #2467942

反应方程式

3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid methyl ester

KOH

→

3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid

收率 83.7%

溶剂

ethanol

反应条件

后处理

1. 1
   其他After the solvent was evaporated from the reaction mixture
2. 2
   workup.DISSOLUTIONthe residue was dissolved
3. 3
   workup.ADDITIONby adding water
4. 4
   其他The produced precipitates
5. 5
   过滤were filtered with suction
6. 6
   洗涤washed with water

实验过程

To a solution of 3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid methyl ester (74 mg, 0.2 mmol) dissolved in ethanol (4 mL) was added 1N—KOH (0.5 mL, 0.5 mmol) and the mixture was stirred at room temperature for 2 hours. After the solvent was evaporated from the reaction mixture, the residue was dissolved by adding water and acidified (H=2) with 2N—HCl under ice cooling. The produced precipitates were filtered with suction, washed with water to afford 59 mg (yield 80%) of the desired 3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid as white solids.

来源