反应 #2467938

反应方程式

4b

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid

MeOH

thionylchloride

→

desired product

3-Phenyl-2-[(4-phenyl-thiazol-2-yl)-hydrazono]-propionic acid methyl ester

反应条件

后处理

1. 1
   温度The reaction mixture was heated
2. 2
   温度to reflux
3. 3
   浓缩concentrated

实验过程

To a suspension of 4b (0.1 mmol, 34 mg) in MeOH (2 mL), was added dropwise thionylchloride (22 μL, 0.3 mmol) at −30° C. Then, the solution was allowed to warm at room temperature. The reaction mixture was heated to reflux and concentrated to afford the desired product. The crude is purified by silica gel chromatography (EtOAc/MeOH 10/1) to give the pure compound as a yellow solid (11 mg, 32%).

来源