反应 #2460359

反应方程式

5-bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine

acetate

K2CO3

→

title compound

收率 19.5%

{4-[5-amino-6-(1-ethyl-1-H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-yl]phenoxy}acetic acid

收率 19.5%

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   浓缩The reaction mixture was concentrated in vacuo
2. 2
   其他the residue purified by mass

实验过程

5-bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine (0.032 g, 0.10 mmol) (made in example 2), tert-butyl[4,4,5,5-tetramethyl-1,3,2-dioxaboralan-2-yl)phenoxy]acetate (0.067 g, 0.20 mmol), Pd(PPh3)2Cl2 (0.0035 g, 0.005 mmol) and K2CO3 (0.050 g, 0.36 mmol) were combined in 0.5 mL of N,N-dimethylformamide and heated to 200° C. in the SmithSynthesizer microwave for 8 minutes and then for a further 8 minutes at 250° C. The reaction mixture was concentrated in vacuo and the residue purified by mass directed HPLC to give 0.0038 g of the title compound.

来源