反应 #2460358

反应方程式

4-Bromophenol

sodium hydride

t-Butylbromoacetate

→

tert-butyl(4-bromophenoxy)acetate

收率 82.9%

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   浓缩The reaction was concentrated in vacuo
2. 2
   其他the residue partitioned between ethyl acetate and water
3. 3
   洗涤The organic phase was washed with saturated ammonium acetate
4. 4
   浓缩concentrated in vacuo

实验过程

4-Bromophenol (20.4 g, 118 mmol) dissolved in dry N,N-dimethylformamide was carefully treated with sodium hydride (4 g, 167 mmol). t-Butylbromoacetate (23 g, 118 mmol) was added and the mixture heated to 75° C. for 90 minutes. The reaction was concentrated in vacuo and the residue partitioned between ethyl acetate and water. The organic phase was washed with saturated ammonium acetate and concentrated in vacuo to yield 28.1 g of tert-butyl(4-bromophenoxy)acetate.

来源