反应 #2460349

反应方程式

Sodium sulfite

3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine

N-bromosuccinimide

→

5-bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine

收率 81.8%

溶剂

THF

反应条件

后处理

1. 1
   workup.STIRRINGstirred vigorously for 30 minutes
2. 2
   浓缩The mixture was then concentrated to dryness
3. 3
   workup.ADDITIONtreated with water
4. 4
   其他After sonication
5. 5
   其他the solids were collected
6. 6
   过滤on filter
7. 7
   洗涤Rinsing (×2) with diethyl ether

实验过程

To a solution of 3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine (0.45 g, 1.8 mmol) (see Example 1) in THF is added N-bromosuccinimide (0.37 g, 2.1 mmol). The reaction is stirred for 4 hours at ambient temperature. Sodium sulfite (excess) was added and stirred vigorously for 30 minutes. The mixture was then concentrated to dryness and treated with water. After sonication, the solids were collected on filter. Rinsing (×2) with diethyl ether afforded 5-bromo-3-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)pyrazin-2-amine (0.47 g, 79%) as tan solids.

来源